Biomaterials for Bone Repair
Design of biodegradable and bioactive scaffolds for infectious bone defects, large bone defects, mandibular repair, and osteogenic microenvironments.
Research
The research program centers on biomaterials design, biofabrication, and translational regenerative medicine, with a strong emphasis on 3D printing, shape-memory polymers, hydrogels, and clinically relevant scaffold systems.
Research Vision
Our work aims to build intelligent biomaterial systems that do more than fill tissue defects: they regulate immune responses, deliver therapeutics, guide osteogenesis, support vascularization, and match the geometric and mechanical complexity of damaged tissues.
A recurring theme is the development of minimally invasive and structurally adaptive implants, including shape-memory scaffolds, porous microsphere assemblies, multifunctional hydrogels, and 3D-printed biomimetic architectures.
Application Areas
- Infectious bone defect repair
- Large bone defect regeneration
- Cartilage repair and osteochondral regeneration
- Diabetic wound healing and infected wound management
- Intervertebral disc regeneration
- Endometrial and other soft-tissue repair applications
3D Bioprinting and Shape-Memory Platforms
Development of 3D-printed and 4D-printed scaffold systems with minimally invasive delivery, adaptive filling behavior, and structural biomimicry.
Hydrogels and Regenerative Microenvironments
Injectable and dual-network hydrogel systems for wound healing, cartilage repair, intervertebral disc regeneration, and cell-responsive tissue repair.
Polymer Synthesis and Processing
Polymer design, terpolymer systems, microsphere fabrication, and materials processing strategies that couple mechanics, degradability, and biofunctionality.
Technical Strengths
- 3D printing and 4D printing of scaffold systems
- Shape-memory polymer and terpolymer design
- Hydrogel crosslinking and multifunctional modification
- Microsphere scaffold fabrication and hierarchical porosity
- Drug-loading strategies for antibacterial and osteoimmunomodulatory repair
Representative Themes from Recent Papers
- Triple-acting liposomal strategies in 4D-printed shape-memory scaffolds
- Thermoresponsive terpolymers for minimally invasive surgery
- Hydrogel–nanoparticle systems for infected diabetic wound repair
- Polymer microsphere scaffolds and immunomodulatory bone regeneration
- Injectable biomaterials for intervertebral disc and cartilage regeneration