Sichuan Natural Science Foundation (General Program)
Thermoresponsive Shape-Memory Filling Scaffolds for Sequential Immunomodulation–Osteogenesis Cascade Repair of Bone Defects
Grant No. 2026NSFSC0599
Biomaterials · Bioprinting · Regenerative Medicine
Xulin Hu
Associate Professor · Master's Supervisor
Xulin Hu is an Associate Professor and Master's Supervisor at the Clinical Medical College of Chengdu University and the Affiliated Hospital of Chengdu University. He received his B.Sc. in Chemistry from Sichuan University, earned his doctoral degree in Polymer Chemistry and Physics from the University of Chinese Academy of Sciences, and completed postdoctoral research at the State Key Laboratory of Biotherapy, Sichuan University. His research focuses on biomedical engineering, bioprinting, tissue engineering and regenerative repair, as well as polymer synthesis and processing.
50
Listed publications
7
Funded projects as PI
30+
SCI papers as first/corresponding author
2
Highly cited papers
Profile
Dr. Hu's work lies at the interface of biomaterials science, biofabrication, and translational regenerative medicine. His recent studies emphasize 3D-printed and shape-memory scaffolds, multifunctional hydrogels, porous microsphere systems, and minimally invasive implantable platforms for infectious bone defects, cartilage regeneration, diabetic wound healing, intervertebral disc repair, and related musculoskeletal applications. He has published more than 30 SCI papers as first or corresponding author, including highly cited work, and has led multiple national and provincial research projects.
He has co-supervised more than ten doctoral and master's students and mentored more than twenty undergraduate students. As first supervisor, he guided student teams that received project support under the 2023 Undergraduate Innovation Training Program, a National Bronze Award in the 10th National Forum on Basic Medical Innovation and Experimental Design, and a National First Prize in the 10th National Life Science Competition (Scientific Inquiry Track).
He also serves on editorial or youth editorial boards for journals including Exploration, Chinese Chemical Letters, and Cell Proliferation.
Research Focus
- 3D-printed and 4D-printed biomaterial platforms
- Shape-memory scaffolds for minimally invasive implantation
- Hydrogel and microsphere systems for regenerative repair
- Polymer-based scaffold design for infectious bone defects
- Tissue engineering strategies for wound, cartilage, disc, and endometrial repair
Current materials emphasize translational biomaterial systems that integrate mechanics, degradability, drug delivery, immunomodulation, and structural biomimicry.
Selected Publications
A selection of recent representative papers. The full publication list is available on the Publications page.
- Yingkun Hu, Shuhao Yang, Yan Fang, Zhenghao Xu, Jianye Yang, Qinyang Zhang, Chengqiang Zhou, Xulin Hu*, Ning Hu, Li Chen. Porous microsphere-based one-stop repair platform mobilizes endogenous mesenchymal stem cells and recapitulates hypoxic metabolism for cartilage regeneration. Chemical Engineering Journal. 2026, 529, 172649.
- Xulin Hu#, Shuhao Yang, Qianshui Hu, Zhengguang Pu, Yingkun Hu, Wang Gong, Haoming Wu, Zhixiang Gao, Jun Wang, Jianye Yang, Yao Zhang, Xin Yong, Leilei Qin, Ning Hu,. Spatiotemporal 4D-printed shape-memory scaffold with a triple-acting liposomal strategy for the treatment of infectious bone defects. Biomaterials. 2026, 330, 124020.
- Shengwen Cheng#, Xin Dai, Pengcheng Xiao, Xiaohong Luo, Junyan Liu, Senrui Liu, Yingjie Wu, Zhen Fan, Yixuan Lan, Mingfei Dong, Jun Wang, Chao Peng, Yu Zhai, Jinping Chen, Wei Huang*, Xulin Hu*, Chen Zhao*. Physiologically Responsive Shape-Memory Biomimetic Scaffold for Intelligent Bone Repair: Integrating Drug Delivery with Osteocyte Network Regeneration. Chemical Engineering Journal. 2025, 526, 171457.
- X. Hu#, J. He, L. Qiao, C. Wang, Y. Wang, R. Yu, W. Xu, F. Wang, S. Yang, X. Zhang, Z. Qian, Multifunctional Dual Network Hydrogel Loaded with Novel Tea Polyphenol Magnesium Nanoparticles Accelerates Wound Repair of MRSA Infected Diabetes. Adv. Funct. Mater. 2024, 2312140.
- X. Hu#, J. Chen, S. Yang, Z. Zhang, H. Wu, J. He, L. Qin, J. Cao, C. Xiong, K. Li, X. Liu, Z. Qian, 3D Printed Multifunctional Biomimetic Bone Scaffold Combined with TP-Mg Nanoparticles for the Infectious Bone Defects Repair. Small 2024, 2403681.
- Hu X#, Zhao W, Zhang Z, Xie J, He J, Cao J, Li Q, Yan Y, Xiong C*, Li K*, Novel 3D printed shape-memory PLLA-TMC/GA-TMC scaffolds for bone tissue engineering with the improved mechanical properties and degradability, Chinese Chemical Letters, 2023, 34, 107451.
Recent Funded Projects
Representative competitive grants led by Xulin Hu as principal investigator.
National Natural Science Foundation of China (Young Scientists Fund)
Construction of a 3D-Printed Shape-Memory PTG/TCP/CS@PS-EGCG Scaffold and Its Fundamental Study for Infectious Bone Defects
Grant No. 82402822
Central Government-Guided Local Science and Technology Development Project
Application-Oriented Fundamental Study of Cell Stress-Responsive Viscoelastic 3D-Printed Minimally Invasive Implantable Scaffolds for Irregular Bone Defects
Grant No. 2024ZYD0155
Youth Nursery Project, Sichuan Provincial Health Commission
Application-Oriented Fundamental Study of 3D-Printed Multifunctional Biomimetic Scaffolds Loaded with TP-Mg Nanoparticles for Infectious Bone Defect Repair
Grant No. 24QNMP036
Sichuan Natural Science Foundation
Construction of a Novel 3D-Printed Shape-Memory Polymer Composite Scaffold System and Its Fundamental Study for Infectious Bone Defects
Grant No. 23NSFSC5880
Youth Medical Research Innovation Project, Sichuan Medical Association
Application Study of a Fully Biodegradable Minimally Invasive Drug-Loaded Scaffold System for Infectious Bone Defects
Grant No. Q2024092